The latest medical research on Dermatopathology
The research magnet gathers the latest research from around the web, based on your specialty area. Below you will find a sample of some of the most recent articles from reputable medical journals about dermatopathology gathered by our medical AI research bot.
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Request AccessBET inhibition sensitizes innate checkpoint inhibitor resistant melanoma to anti-CTLA-4 treatment.
Pigment Cell and Melanoma ResearchApproximately 50% of melanoma patients fail to respond to immune checkpoint blockade (ICB), and acquired resistance hampers long-term survival in a...
Genotypic spectrum of albinism in Mali.
Pigment Cell and Melanoma ResearchAlbinism is a phenotypically and genetically heterogeneous condition characterized by a variable degree of hypopigmentation and by ocular features ...
Effects of EGFR-TKI on epidermal melanin unit integrity: Therapeutic implications for hypopigmented skin disorders.
Pigment Cell and Melanoma ResearchEpidermal melanin unit integrity is crucial for skin homeostasis and pigmentation. Epidermal growth factor (EGF) receptor (EGFR) is a pivotal playe...
RNA M6A modification shaping cutaneous melanoma tumor microenvironment and predicting immunotherapy response.
Pigment Cell and Melanoma ResearchRecent years have seen rising mortality rates linked to cutaneous melanoma (SKCM), despite advances in immunotherapy. Understanding RNA N6-methylad...
Molecular heterogeneity of quiescent melanocyte stem cells revealed by single-cell RNA-sequencing.
Pigment Cell and Melanoma ResearchMelanocyte stem cells (McSCs) of the hair follicle are a rare cell population within the skin and are notably underrepresented in whole-skin, singl...
2-Mercaptonicotinoyl glycine, a new potent melanogenesis inhibitor, exhibits a unique mode of action while preserving melanocyte integrity.
Pigment Cell and Melanoma ResearchResearch on new ingredients that can prevent excessive melanin production in the skin while considering efficacy, safety but also environmental imp...
Characterization of PRAME immunohistochemistry reveals lower expression in pediatric melanoma compared to adult melanoma.
Pigment Cell and Melanoma ResearchPediatric melanomas are rare tumors that have clinical and histological differences from adult melanomas. In adult melanoma, the immunohistochemica...
The metabolism of melanin synthesis-From melanocytes to melanoma.
Pigment Cell and Melanoma ResearchMelanin synthesis involves the successful coordination of metabolic pathways across multiple intracellular compartments including the melanosome, m...
Topical antibiotics limit depigmentation in a mouse model of vitiligo.
Pigment Cell and Melanoma ResearchOral neomycin administration impacts the gut microbiome and delays vitiligo development in mice, and topical antibiotics may likewise allow the mic...
Genetic insights into Tietz albinism-deafness syndrome: A new dominant-negative mutation in MITF.
Pigment Cell and Melanoma ResearchTietz albinism-deafness syndrome (TADS) is a rare and severe manifestation of Waardenburg syndrome that is primarily linked to mutations in MITF. I...
Emerging therapeutic strategies for metastatic uveal melanoma: Targeting driver mutations.
Pigment Cell and Melanoma ResearchUveal melanoma (UM) is the most common primary malignant intraocular tumor in adults. Although primary UM can be effectively controlled, a signific...
Review: Are moles senescent?
Pigment Cell and Melanoma ResearchMelanocytic nevi (skin moles) have been regarded as a valuable example of cell senescence occurring in vivo. However, a study of induced nevi in a ...
